Meroterpenoids with Antiproliferative Activity from a Hawaiian-Plant Associated Fungus Peyronellaea coffeae-arabicae FT238

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• 作者：Chun-Shun Li ; Gang Ren ; Bao-Jun Yang ; Gabriella Miklossy ; James Turkson ; Peiwen Fei ; Yuanqing Ding ; Larry A. Walker ; Shugeng Cao
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：May 20, 2016
• 年：2016
• 卷：18
• 期：10
• 页码：2335-2338
• 全文大小：261K
• 年卷期：0
• ISSN：1523-7052

文摘

Three unusual polyketide-sesquiterpene metabolites peyronellins A–C (1–3), along with the new epoxyphomalin analog 11-dehydroxy epoxyphomalin A (4), have been isolated from the endophytic fungus Peyronellaea coffeae-arabicae FT238, which was isolated from the native Hawaiian plant Pritchardia lowreyana. The structures of compounds 1–4 were characterized based on NMR and MS spectroscopic analysis. The absolute configuration (AC) of the compounds was determined by electronic circular dichroism (ECD). Compound 4 showed antiproliferative activity with an IC₅₀ of 0.5 μM against OVCAR3, and it also strongly inhibited Stat3 at 5 μM.