Cu(I)-Catalyzed Tandem Reaction of Carbene Coupling and Horner–Wadsworth–Emmons Type Olefination: Access toward Enynes

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• 作者：Yujing Zhou ; Fei Ye ; Qi Zhou ; Yan Zhang ; Jianbo Wang
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：May 6, 2016
• 年：2016
• 卷：18
• 期：9
• 页码：2024-2027
• 全文大小：415K
• 年卷期：0
• ISSN：1523-7052

文摘

A novel strategy to synthesize 1,3-enynes has been successfully developed based on Cu(I)-catalyzed cross-coupling of α-diazo phosphonates and alkynes with a subsequent Horner–Wadsworth–Emmons (HWE) type reaction. This method provides straightforward access to conjugated enynes with high efficiency, good stereoselectivity and excellent functional group compatibility. Copper(I) carbene migratory insertion plays a crucial role in this transformation.