An approach to (±)-Lingzhiol

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• 作者：Xiaoyu Li ; Xiaoyu Liu ; Xiaozhen Jiao ; Hongguang Yang ; Yangyang Yao ; Ping Xie
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：April 15, 2016
• 年：2016
• 卷：18
• 期：8
• 页码：1944-1946
• 全文大小：322K
• 年卷期：0
• ISSN：1523-7052

文摘

(±)-Lingzhiol has been synthesized from commercially available 5,8-dimethoxytetralone in seven steps with an overall yield of 10.3% via an unprecedented acid-catalyzed semipinacol-type rearrangement. In addition, a novel strategy for the construction of the tetracyclic 5/5/6/6 core structure of lingzhiol has been developed via a tandem rearrangement/reduction/lactonization reaction.