Continuous Liquid Vapor Reactions Part 2: Asymmetric Hydroformylation with Rhodium-Bisdiazaphos Catalysts in a Vertical Pipes-in-Series Reactor

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• 作者：M. Leigh Abrams ; Jonas Y. Buser ; Joel R. Calvin ; Martin D. Johnson ; Bradley R. Jones ; Gordon Lambertus ; Clark R. Landis ; Joseph R. Martinelli ; Scott A. May ; Adam D. McFarland ; James R. Stout
• 刊名：Organic Process Research & Development
• 出版年：2016
• 出版时间：May 20, 2016
• 年：2016
• 卷：20
• 期：5
• 页码：901-910
• 全文大小：738K
• 年卷期：0
• ISSN：1520-586X

文摘

Asymmetric hydroformylation (AHF) of 2-vinyl-6-methoxynaphthalene demonstrates important design characteristics of a vertical pipes-in-series plug flow reactor (PFR). The regio- and enantioselectivity of the AHF reaction provide a chemical probe of gas–liquid mixing in a flow reactor for comparison with well-stirred batch reactors. Results obtained with the flow reactor compare favorably to those obtained in batch. Thus, AHF provides an efficient, in-flow enantioselective synthesis of (S)-Naproxen.