Carbon-Decorated TiO2 Nanotube Membranes: A Renewable Nanofilter for Charge-Selective Enrichment of Proteins

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• 作者：Jingwen Xu ; Lingling Yang ; Yuyao Han ; Yongmei Wang ; Xuemei Zhou ; Zhida Gao ; Yan-Yan Song ; Patrik Schmuki
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2016
• 出版时间：August 31, 2016
• 年：2016
• 卷：8
• 期：34
• 页码：21997-22004
• 全文大小：569K
• 年卷期：0
• ISSN：1944-8252

文摘

In this work, we design a TiO₂ nanomembrane (TiNM) that can be used as a nanofilter platform for selective enrichment of specific proteins. After a first use, the photocatalytic properties of TiO₂ allow the decomposition of unwanted remnants on the substrate and thus make the platform reusable. To construct this platform, we fabricate a free-standing TiO₂ nanotube array and remove the bottom oxide to form a both-end-open TiNM. By pyrolysis of the natural tube wall contamination, the walls become decorated with graphitic carbon patches (C/TiNM). Owing to the large surface area, the amphiphilic nature and the charge-adjustable character, this C/TiNM can be used to extract and enrich hydrophobic charged biomolecules. Using human serum albumin (HSA) as a model protein as well as protein mixtures, we show that the composite membrane exhibits a highly enhanced loading capacity and protein selectivity and is reusable after a short UV treatment.