A Donor–Acceptor Conjugated Polymer with Alternating Isoindigo Derivative and Bithiophene Units for Near-Infrared Modulated Cancer Thermo-Chemotherapy

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• 作者：Dong-Dong Li ; Jun-Xia Wang ; Yan Ma ; Hai-Sheng Qian ; Dong Wang ; Li Wang ; Guobing Zhang ; Longzhen Qiu ; Yu-Cai Wang ; Xian-Zhu Yang
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2016
• 出版时间：August 3, 2016
• 年：2016
• 卷：8
• 期：30
• 页码：19312-19320
• 全文大小：606K
• 年卷期：0
• ISSN：1944-8252

文摘

Conjugated polymers containing alternating donor/acceptor units have strong and sharp absorbance peaks in near-infrared (NIR) region, which could be suitable for photothermal therapy. However, these polymers as photothermal transducers are rarely reported because of their water insolubility, which limits their applications for cancer therapy. Herein, we report the donor–acceptor conjugated polymer PBIBDF-BT with alternating isoindigo derivative (BIBDF) and bithiophene (BT) units as a novel photothermal transducer, which exhibited strong near-infrared (NIR) absorbance due to its low band gap (1.52 eV). To stabilize the conjugated polymer physiological environments, we utilized an amphiphilic copolymer, poly(ethylene glycol)-block-poly(hexyl ethylene phosphate) (mPEG-b-PHEP), to stabilize PBIBDF-BT-based nanoparticles (PBIBDF-BT@NP_PPE) through a single emulsion method. The obtained nanoparticles PBIBDF-BT@NP_PPE showed great stability in physiological environments and excellent photostability. Moreover, the PBIBDF-BT@NP_PPE exhibited high photothermal conversion efficiency, reaching 46.7%, which is relatively high compared with those of commonly used materials for photothermal therapy. Accordingly, in vivo and in vitro experiments demonstrated that PBIBDF-BT@NP_PPE exhibits efficient photothermal anticancer efficacy. More importantly, PBIBDF-BT@NP_PPE could simultaneously encapsulate other types of therapeutic agents though hydrophobic interactions with the PHEP core and achieve NIR-triggered intracellular drug release and a synergistic combination therapy of thermo-chemotherapy for the treatment of cancer.