Switchable Liposomes: Targeting-Peptide-Functionalized and pH-Triggered Cytoplasmic Delivery

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• 作者：Qiuju Han ; Weizhi Wang ; Xiangqian Jia ; Yixia Qian ; Qian Li ; Zihua Wang ; Weikai Zhang ; Shu Yang ; Yunhong Jia ; Zhiyuan Hu
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2016
• 出版时间：July 27, 2016
• 年：2016
• 卷：8
• 期：29
• 页码：18658-18663
• 全文大小：520K
• 年卷期：0
• ISSN：1944-8252

文摘

One switchable nanodelivery system was constructed. Liposomes were functionalized by a novel dual-recognition peptide STP, which is pH-responsive as well as the affinity ligand of tumor marker VEGFR2 (the angiogenesis marker vascular endothelial growth factor receptor 2). Efficient drug delivery and in vivo therapy could be “turned on” and accelerated only in the conditions of VEGFR2 overexpression and a mild acidic environment. We envisioned that the successful demonstration of this switchable nanocarrier system would open a new avenue on rapid cytoplasmic delivery for specific cancer diagnostics and therapeutics.