A Multifunctional PB@mSiO2–PEG/DOX Nanoplatform for Combined Photothermal–Chemotherapy of Tumor

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• 作者：Yun Yan Su ; Zhaogang Teng ; Hui Yao ; Shou Ju Wang ; Ying Tian ; Yun Lei Zhang ; Wen Fei Liu ; Wei Tian ; Li Juan Zheng ; Nan Lu ; Qian Qian Ni ; Xiao Dan Su ; Yu Xia Tang ; Jing Sun ; Ying Liu ; Jiang Wu ; Gui Fen Yang ; Guang Ming Lu ; Long Jiang Zhang
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2016
• 出版时间：July 13, 2016
• 年：2016
• 卷：8
• 期：27
• 页码：17038-17046
• 全文大小：779K
• 年卷期：0
• ISSN：1944-8252

文摘

In this work, we design mesoporous silica-coated Prussian blue nanocubes with PEGyltation to construct multifunctional PB@mSiO₂–PEG nanocubes. The PB@mSiO₂–PEG nanocubes have good biocompatibility, excellent photothermal transformation capacity, in vivo magnetic resonance and photoacoustic imaging ability. After loading antitumor drug doxorubicin (DOX) in the PB@mSiO₂–PEG nanocubes, the constructured PB@mSiO₂–PEG/DOX nanoplatforms show an excellent pH-responsive drug release character within 48 h, namely, an ultralow cumulative drug release amount of 3.1% at pH 7.4 and a high release amount of 46.6% at pH 5.0. Upon near-infrared laser irradiation, the PB@mSiO₂–PEG/DOX nanoplatforms show an enhanced synergistic photothermal and chemical therapeutic efficacy for breast cancer than solo photothermal therapy or chemotherapy.