Antibacterial Activity of Silver Doped Titanate Nanowires on Ti Implants

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• 作者：Ziqiang Xu ; Man Li ; Xia Li ; Xiangmei Liu ; Fei Ma ; Shuilin Wu ; K. W. K. Yeung ; Yong Han ; Paul K. Chu
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2016
• 出版时间：July 6, 2016
• 年：2016
• 卷：8
• 期：26
• 页码：16584-16594
• 全文大小：854K
• 年卷期：0
• ISSN：1944-8252

文摘

A nanostructured film composed of one-dimensional titanate nanowires (TNWs) was employed as a carrier of Ag nanoparticles and chitosan (CS) to improve the surface antibacterial activity and biocompatibility of titanium implants. A TNWs film was produced on a Ti substrate by an alkali hydrothermal reaction and subsequently doped by Ag nanoparticles through an ultraviolet light chemical reduction. The CS nanofilm was deposited on the Ag nanoparticles through a spin-assisted layer by layer assembly method. The results disclosed that Ag nanoparticles were successfully carried by TNWs and homogeneously distributed on the entire surface. Moreover, a CS nanofilm was also successfully deposited on the Ag nanoparticles. Antibacterial tests showed that the samples modified with a higher initial concentration of AgNO₃ solution exhibited better antibacterial activity, and that a CS nanofilm could further improve the antibacterial activity of the TNWs. Cell viability and ALP tests revealed that the release of Ag⁺ was detrimental for the growth, proliferation, and differentiation of MC3T3, and that CS could lower the negative effects of Ag gradually as the incubation time increased.