Outstanding Antibiofilm Features of Quanta-CuO Film on Glass Surface

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• 作者：Nirmalya Tripathy ; Rafiq Ahmad ; Seung Hyuck Bang ; Gilson Khang ; Jiho Min ; Yoon-Bong Hahn
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2016
• 出版时间：June 22, 2016
• 年：2016
• 卷：8
• 期：24
• 页码：15128-15137
• 全文大小：677K
• 年卷期：0
• ISSN：1944-8252

文摘

Intelligently designed surface nanoarchitecture provides defined control over the behavior of cells and biomolecules at the solid–liquid interface. In this study, CuO quantum dots (quanta-CuO; ∼3–5 nm) were synthesized by a simple, low-temperature solution process and further formulated as paint to construct quanta-CuO thin film on glass. Surface morphological characterizations of the as-coated glass surface reveal a uniform film thickness (∼120 ± 10 nm) with homogeneous distribution of quanta-CuO. The antibiofilm assay showed a very high contact bacteria-killing capacity of as-coated quanta-CuO glass surfaces toward Staphylococcus aureus and Escherichia coli. This efficient antibacterial/antibiofilm activity was ascribed to the intracellular reactive oxygen species (ROS) generated by the quanta-CuO attached to the bacterial cells, which leads to an oxidative assault and finally results in bacterial cell death. Although there is a significant debate regarding the CuO nanostructure’s antibacterial mode of action, we propose both contact killing and/or copper ion release killing mechanisms for the antibiofilm activity of quanta-CuO paint. Moreover, synergism of quanta-CuO with conventional antibiotics was also found to further enhance the antibacterial efficacy of commonly used antibiotics. Collectively, this state-of-the-art design of quanta-CuO coated glass can be envisioned as promising candidates for various biomedical and environmental device coatings.