Facile Synthesis of Uniform-Sized Bismuth Nanoparticles for CT Visualization of Gastrointestinal Tract in Vivo

详细信息    查看全文

• 作者：Boxiong Wei ; Xuejun Zhang ; Cai Zhang ; Ying Jiang ; Yan-Yan Fu ; Chunshui Yu ; Shao-Kai Sun ; Xiu-Ping Yan
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2016
• 出版时间：May 25, 2016
• 年：2016
• 卷：8
• 期：20
• 页码：12720-12726
• 全文大小：496K
• 年卷期：0
• ISSN：1944-8252

文摘

High-performance and biocompatible contrast agents are the key to accurate diagnosis of various diseases in vivo via CT imaging. Fabrication of pure Bi nanoparticles is the best way to maximize X-ray absorption efficiency due to the ultrahigh X-ray attenuation ability of Bi and 100% content of Bi element. However, high-quality Bi nanoparticles prepared through a facile strategy are still lacking. Herein, we report a simple noninjection method to fabricate uniformly sized pure Bi nanoparticles using only two commercial reagents by simply heating the mixture of raw materials in a short time. The obtained Bi nanoparticles owned highly uniform size, excellent monodispersity, and impressive antioxidant capacity. After being modified with oligosaccharide, the “sweet” Bi nanoprobe with comfortable patient experience and favorable biocompatibility was successfully used in CT visualization of gastrointestinal tract in detail.