Engineering Lysosome-Targeting BODIPY Nanoparticles for Photoacoustic Imaging and Photodynamic Therapy under Near-Infrared Light

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• 作者：Wenbo Hu ; Hengheng Ma ; Bing Hou ; Hui Zhao ; Yu Ji ; Rongcui Jiang ; Xiaoming Hu ; Xiaomei Lu ; Lei Zhang ; Yufu Tang ; Quli Fan ; Wei Huang
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2016
• 出版时间：May 18, 2016
• 年：2016
• 卷：8
• 期：19
• 页码：12039-12047
• 全文大小：557K
• 年卷期：0
• ISSN：1944-8252

文摘

Developing lysosome-targeting organic nanoparticles combined with photoacoustic imaging (PAI) and photodynamic therapy (PDT) functions toward personalized medicine are highly desired yet challenging. Here, for the first time, lysosome-targeting BODIPY nanoparticles were engineered by encapsulating near-infrared (NIR) absorbed BODIPY dye within amphiphilic DSPE-mPEG5000 for high-performing lysosomal PAI and acid-activatable PDT against cancer cells under NIR light.