Bromo-Substituted Diketopyrrolopyrrole Derivative with Specific Targeting and High Efficiency for Photodynamic Therapy

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• 作者：Yu Cai ; Qianyun Tang ; Xiujuan Wu ; Weili Si ; Qi Zhang ; Wei Huang ; Xiaochen Dong
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2016
• 出版时间：May 4, 2016
• 年：2016
• 卷：8
• 期：17
• 页码：10737-10742
• 全文大小：515K
• 年卷期：0
• ISSN：1944-8252

文摘

Novel photosensitizers with high reactive oxygen species generation and precise targeting to tumors are crucial for photodynamic therapy (PDT). Here, a bromo-substituted diketopyrrolopyrrole derivative (2,5-bis(6-bromohexyl)-3,6-bis(5-bromothiophene-2-yl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione)-grafted hyaluronic acid is synthesized, which presents excellent targeting and PDT efficiency both in vitro and in vivo.