N-Heterocyclic Carbenes in Asymmetric Hydrogenation

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• 作者：Dongbing Zhao ; Lisa Candish ; Daniel Paul ; Frank Glorius
• 刊名：ACS Catalysis
• 出版年：2016
• 出版时间：September 2, 2016
• 年：2016
• 卷：6
• 期：9
• 页码：5978-5988
• 全文大小：906K
• 年卷期：0
• ISSN：2155-5435

文摘

N-heterocyclic carbene (NHC)-metal complexes have become known as efficient catalysts for numerous transition metal catalyzed processes. An important application of many NHC-metal complexes is in the field of asymmetric catalysis, and this is achieved through the introduction of chiral information on the NHC ligands. Among the asymmetric transformations catalyzed by NHC-metal complexes is asymmetric hydrogenation, which is an attractive process for the synthesis of optically active compounds due to its high atom economy. However, to date, few chiral NHC-metal catalysts have been reported to be highly stereoselective for asymmetric hydrogenation. Over the past few years our group has made some significant breakthroughs within the field of asymmetric hydrogenation using chiral NHC catalysts. We have reported the NHC-Ru catalyzed asymmetric hydrogenation of a wide range of heterocyclic compounds with high regio- and enantioselectivity. The field of chiral NHC-metal complex catalyzed asymmetric hydrogenation is yet to be reviewed; this Perspective aims to provide a concise overview of NHC-metal catalyzed asymmetric hydrogenation to push the further development of this area of chemistry.