Enantioselective Synthesis of Pyrrole-Fused Piperazine and Piperazinone Derivatives via Ir-Catalyzed Asymmetric Allylic Amination

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• 作者：Chun-Xiang Zhuo ; Xiao Zhang ; Shu-Li You
• 刊名：ACS Catalysis
• 出版年：2016
• 出版时间：August 5, 2016
• 年：2016
• 卷：6
• 期：8
• 页码：5307-5310
• 全文大小：393K
• 年卷期：0
• ISSN：2155-5435

文摘

Ir-catalyzed intramolecular asymmetric allylic amination reaction of pyrrole derivatives was achieved. The pyrrole-fused piperazine and piperazinone derivatives could be easily accessed from the pyrrole-tethered allylic carbonates in good yields and enantioselectivity (up to 98% ee).