Functionalized Polymer-Supported Pyridine Ligands for Palladium-Catalyzed C(sp3)–H Arylation

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• 作者：Li-Chen Lee ; Jian He ; Jin-Quan Yu ; Christopher W. Jones
• 刊名：ACS Catalysis
• 出版年：2016
• 出版时间：August 5, 2016
• 年：2016
• 卷：6
• 期：8
• 页码：5245-5250
• 全文大小：375K
• 年卷期：0
• ISSN：2155-5435

文摘

The use of ligands to tune the reactivity and selectivity of transition-metal catalysts for C(sp³)–H bond activation is a current central challenge. One of us previously developed an uncommon example of a homogeneous catalyst that performs controlled C(sp³)–H arylation using pyridine derivatives as ligands, along with Pd [Science, 2014, 343, 1216–1220]. In this work, we report a functionalizable and tunable polymer support used in the immobilization of pyridine derivatives that yields a soluble, polymeric ligand platform facilitating C(sp³)–H activation reactions with good yields, selectivities differing from the homogeneous catalyst, and recovery of Pd. Unlike the homogeneous system, the supported catalysts in Pd-catalyzed C–H monoarylation reactions respond sensitively to the steric hindrance of the coupling partners.