Nonenzymatic and Metal-Free Organocatalysis for in Situ Regeneration of Oxidized Cofactors by Activation and Reduction of Molecular Oxygen

详细信息    查看全文

• 作者：Chenjie Zhu ; Qing Li ; Lingling Pu ; Zhuotao Tan ; Kai Guo ; Hanjie Ying ; Pingkai Ouyang
• 刊名：ACS Catalysis
• 出版年：2016
• 出版时间：August 5, 2016
• 年：2016
• 卷：6
• 期：8
• 页码：4989-4994
• 全文大小：412K
• 年卷期：0
• ISSN：2155-5435

文摘

The application of synthetic flavinium organocatalysts for the in situ regeneration of oxidized cofactors NAD(P)⁺ using O₂ as the terminal oxidant without any special illumination or equipment is reported. With the aid of the highly active bridged flavinium catalyst, the rate of NAD(P)H oxidation is accelerated by 3 orders of magnitude. The results show that the catalytic activity of the bridged flavinium catalyst is not dependent on light but on only oxygen. Furthermore, this catalyst is compatible with various preparative enzymatic oxidation reactions. A hydride transfer mechanism is proposed for the presented system.