Nickel-Catalyzed Csp2–Csp3 Cross-Coupling via C–O Bond Activation

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• 作者：Lin Guo ; Chien-Chi Hsiao ; Huifeng Yue ; Xiangqian Liu ; Magnus Rueping
• 刊名：ACS Catalysis
• 出版年：2016
• 出版时间：July 1, 2016
• 年：2016
• 卷：6
• 期：7
• 页码：4438-4442
• 全文大小：424K
• 年卷期：0
• ISSN：2155-5435

文摘

A new and efficient nickel-catalyzed alkylation of C_Ar–O electrophiles with B-alkyl-9-BBNs is described. The transformation is characterized by its functional group tolerance and provides a practical and versatile access to various C_sp2–C_sp3 bonds through C_sp2–O substitution, without the restriction of β-hydride elimination. Moreover, the advantage of the newly developed method was demonstrated in a selective and sequential C–O bond activation process.