Merging C–H Bond Functionalization with Amide Alcoholysis: En Route to 2-Aminopyridines

详细信息    查看全文

• 作者：Dinesh Kumar ; Sandeep R. Vemula ; Gregory R. Cook
• 刊名：ACS Catalysis
• 出版年：2016
• 出版时间：June 3, 2016
• 年：2016
• 卷：6
• 期：6
• 页码：3531-3536
• 全文大小：650K
• 年卷期：0
• ISSN：2155-5435

文摘

A new route for the synthesis of 2-aminopyridines has been developed that merges C–H functionalization with amide alcoholysis. The key component of this method is the ability of a quinazolinone to template the chemo- and regioselective construction of a latent pyridine ring via site-selective olefinic C–H bond functionalization under Ru(II) catalysis. Thus, highly substituted 2-aminopyridines were prepared in good yield. Mechanistic studies provide insight into the mechanism of the key oxidative C–H activation/annulation process.