One-Pot Access to a Library of Dispiro Oxindole-pyrrolidine/pyrrolothiazole-thiochromane Hybrids via Three-Component 1,3-Dipolar Cycloaddition Reactions

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• 作者：Gandhi Uma Rani ; Sundaravel Vivek Kumar ; Chelliah Bharkavi ; J. Carlos Menéndez ; Subbu Perumal
• 刊名：ACS Combinatorial Science
• 出版年：2016
• 出版时间：June 13, 2016
• 年：2016
• 卷：18
• 期：6
• 页码：337-342
• 全文大小：404K
• 年卷期：0
• ISSN：2156-8944

文摘

A library of novel dispiro compounds containing oxindole pyrrolidine/oxindolopyrrolothiazole-thiochroman-4-one hybrid frameworks has been synthesized in a fully regio- and stereoselective fashion by the three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ from the condensation of isatins and secondary amino acids (sarcosine/l-thioproline) with 3-arylidenethiochroman-4-ones. This experimentally simple protocol provides good yields of structurally complex, biologically relevant heterocycles in a single operation.