A Naturally Derived, Growth Factor-Binding Polysaccharide for Therapeutic Angiogenesis

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• 作者：Qiu Li ; Guangxing Guo ; Fancheng Meng ; Helena H. Wang ; Yiming Niu ; Qingwen Zhang ; Junfeng Zhang ; Yitao Wang ; Lei Dong ; Chunming Wang
• 刊名：ACS Macro Letters
• 出版年：2016
• 出版时间：May 17, 2016
• 年：2016
• 卷：5
• 期：5
• 页码：617-621
• 全文大小：331K
• 年卷期：0
• ISSN：2161-1653

文摘

We herein report the discovery of a naturally derived carbohydrate with binding affinities for two pro-angiogenic growth factors–fibroblast growth factor-2 (FGF-2) and platelet-derived growth factor-BB (PDGF-BB). This galacturonic acid-containing polysaccharide (EUP3) sequestered endogenous FGF-2 and PDGF-BB in vivo and promoted in situ formation and maturation of new blood vessels. Our findings suggest EUP3 as the first nonglycosaminoglycan, nonanimal-originated carbohydrate molecule that binds two pro-angiogenic growth factors to stimulate angiogenesis. Further investigations into this carbohydrate may lead to the development of new tools for therapeutic angiogenesis.