Micromixer Based Preparation of Functionalized Liposomes and Targeting Drug Delivery

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• 作者：Xiangqian Jia ; Weizhi Wang ; Qiuju Han ; Zihua Wang ; Yunhong Jia ; Zhiyuan Hu
• 刊名：ACS Medicinal Chemistry Letters
• 出版年：2016
• 出版时间：April 14, 2016
• 年：2016
• 卷：7
• 期：4
• 页码：429-434
• 全文大小：430K
• 年卷期：0
• ISSN：1948-5875

文摘

We present here a specific targeting nanocarrier system by functionalization of liposomes with one new type of breast cancer targeting peptide (H6, YLFFVFER) by a micromixer with high efficiency. Antitumor drugs could be successfully delivered into human epidermal growth factor receptor 2 (HER2) positive breast cancer cells with high efficiency in both in vivo and ex vivo models.