Light-Induced Acid Generation on a Gatekeeper for Smart Nitric Oxide Delivery

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• 作者：Hyung Woo Choi ; Jihoon Kim ; Jinhwan Kim ; Yonghwi Kim ; Hyun Beom Song ; Jeong Hun Kim ; Kimoon Kim ; Won Jong Kim
• 刊名：ACS Nano
• 出版年：2016
• 出版时间：April 26, 2016
• 年：2016
• 卷：10
• 期：4
• 页码：4199-4208
• 全文大小：534K
• 年卷期：0
• ISSN：1936-086X

文摘

We report herein the design of a light-responsive gatekeeper for smart nitric oxide (NO) delivery. The gatekeeper is composed of a pH-jump reagent as an intermediary of stimulus and a calcium phosphate (CaP) coating as a shielding layer for NO release. The light irradiation and subsequent acid generation are used as triggers for uncapping the gatekeeper and releasing NO. The acids generated from a light-activated pH-jump agent loaded in the mesoporous nanoparticles accelerated the degradation of the CaP-coating layers on the nanoparticles, facilitating the light-responsive NO release from diazeniumdiolate by exposing a NO donor to physiological conditions. Using the combination of the pH-jump reagent and CaP coating, we successfully developed a light-responsive gatekeeper system for spatiotemporal-controlled NO delivery.