Isoprene-Derived Secondary Organic Aerosol Induces the Expression of Oxidative Stress Response Genes in Human Lung Cells

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• 作者：Ying-Hsuan Lin ; Maiko Arashiro ; Elizabeth Martin ; Yuzhi Chen ; Zhenfa Zhang ; Kenneth G. Sexton ; Avram Gold ; Ilona Jaspers ; Rebecca C. Fry ; Jason D. Surratt
• 刊名：Environmental Science & Technology Letters
• 出版年：2016
• 出版时间：June 14, 2016
• 年：2016
• 卷：3
• 期：6
• 页码：250-254
• 全文大小：323K
• 年卷期：0

文摘

Atmospheric oxidation of isoprene in the presence of acidic sulfate aerosol leads to secondary organic aerosol (SOA) that substantially contributes to the mass of outdoor fine particulate matter (PM_2.5). The potential adverse health effects resulting from exposure to this PM type are largely unknown. Isoprene-derived epoxides, isoprene epoxydiols (IEPOX) and methacrylic acid epoxide (MAE), have recently been identified as key gaseous intermediates leading to isoprene SOA formation through acid-catalyzed multiphase chemistry. Altered expression of oxidative stress-associated genes was assessed from exposure to laboratory-generated IEPOX- and MAE-derived SOA in an in vitro model of human airway epithelial cells (BEAS-2B). Exposure to SOA filter extracts is associated with an increased level of expression of oxidative stress response genes in human lung cells under noncytotoxic conditions, with MAE-derived SOA extracts showing greater potency than IEPOX-derived SOA extracts. Our findings highlight the importance of future work aimed at linking PM source, composition, exposure biomarkers, and health outcomes.