Single-File Diffusion of Protein Drugs through Cylindrical Nanochannels

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• 作者：Seung Yun Yang ; Jeong-A Yang ; Eung-Sam Kim ; Gumhye Jeon ; Eun Ju Oh ; Kwan Yong Choi ; Sei Kwang Hahn ; Jin Kon Kim
• 刊名：ACS Nano
• 出版年：2010
• 出版时间：July 27, 2010
• 年：2010
• 卷：4
• 期：7
• 页码：3817-3822
• 全文大小：340K
• 年卷期：0
• ISSN：1936-086X

文摘

A new drug delivery device using cylindrical block copolymer nanochannels was successfully developed for controlled protein drug delivery applications. Depending on the hydrodynamic diameter of the protein drugs, the pore size in cylindrical nanochannels could be controlled precisely down to 6 nm by Au deposition. Zero-order release of bovine serum albumin (BSA) and human growth hormone (hGH) by single-file diffusion, which has been observed for gas diffusion through zeolite pores, was realized up to 2 months without protein denaturation. Furthermore, a nearly constant in vivo release of hGH from the drug delivery nanodevice implanted to Sprague−Dawley (SD) rats was continued up to 3 weeks, demonstrating the feasibility for long-term controlled delivery of therapeutic protein drugs.