Host−Guest Interaction Mediated Polymeric Assemblies: Multifunctional Nanoparticles for Drug and Gene Delivery

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• 作者：Jianxiang Zhang ; Hongli Sun ; Peter X. Ma
• 刊名：ACS Nano
• 出版年：2010
• 出版时间：February 23, 2010
• 年：2010
• 卷：4
• 期：2
• 页码：1049-1059
• 全文大小：624K
• 年卷期：0
• ISSN：1936-086X

文摘

Novel core−shell structured nanoassemblies are assembled by a β-cyclodextrin containing a positively charged host polymer and a hydrophobic guest polymer. The hydrophobic core of these types of assemblies serves as a nanocontainer to load and release the hydrophobic drugs, while the positively charged hydrophilic shell is able to condense the plasmid DNA and achieve its transfection/expression in osteoblast cells. These assemblies may be used as a new generation of multifunctional nanocarriers for simultaneous drug delivery and gene therapy.