Rapid Determination of Enantiomeric Excess via NMR Spectroscopy: A Research-Informed Experiment

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• 作者：John S. Fossey ; Eric V. Anslyn ; William D. G. Brittain ; Steven D. Bull ; Brette M. Chapin ; Cécile S. Le Duff ; Tony D. James ; Glenn Lees ; Stephanie Lim ; Jennifer A. C. Lloyd ; Charles V. Manville ; Daniel T. Payne ; Kimberley A. Roper
• 刊名：Journal of Chemical Education
• 出版年：2017
• 出版时间：January 10, 2017
• 年：2017
• 卷：94
• 期：1
• 页码：79-84
• 全文大小：265K
• ISSN：1938-1328

文摘

An undergraduate chemistry experiment that draws from primary research is described. The experiment exploits chiral supramolecular assemblies for the determination of enantiomeric excess by ¹H NMR spectroscopy. This report describes the delivery of the experiment to a cohort of students, and as a result of feedback from those involved, an optimized protocol is presented. Particular care has been taken to facilitate ready adoption in other institutions by providing comprehensive teaching support materials as well as technical guidance for supporting the experiment.