New Approaches to Investigate Drug-Induced Hypersensitivity

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• 作者：Monday O. Ogese ; Shaheda Ahmed ; Ana Alferivic ; Catherine J. Betts ; Anne Dickinson ; Lee Faulkner ; Neil FrenchAndrew Gibson ; Gideon M. Hirschfield ; Michael Kammüller ; Xiaoli Meng ; Stefan F. MartinPhilippe Musette ; Alan Norris ; Munir Pirmohamed ; B. Kevin Park ; Anthony W. Purcell ; Colin F. Spraggs ; Jessica WhritenourDean J. Naisbitt
• 刊名：Chemical Research in Toxicology
• 出版年：2017
• 出版时间：January 17, 2017
• 年：2017
• 卷：30
• 期：1
• 页码：239-259
• 全文大小：749K
• ISSN：1520-5010

文摘

The workshop on “New Approaches to Investigate Drug-Induced Hypersensitivity” was held on June 5, 2014 at the Foresight Center, University of Liverpool. The aims of the workshop were to (1) discuss our current understanding of the genetic, clinical, and chemical basis of small molecule drug hypersensitivity, (2) highlight the current status of assays that might be developed to predict potential drug immunogenicity, and (3) identify the limitations, knowledge gaps, and challenges that limit the use of these assays and utilize the knowledge gained from the workshop to develop a pathway to establish new and improved assays that better predict drug-induced hypersensitivity reactions during the early stages of drug development. This perspective reviews the clinical and immunological bases of drug hypersensitivity and summarizes various experts’ views on the different topics covered during the meeting.