Synthetic Strategies Employed for the Construction of Fostriecin and Related Natural Products

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• 作者：Barry M. Trost ; Joshua D. Knopf ; Cheyenne S. Brindle
• 刊名：Chemical Reviews
• 出版年：2016
• 出版时间：December 28, 2016
• 年：2016
• 卷：116
• 期：24
• 页码：15035-15088
• 全文大小：4088K
• ISSN：1520-6890

文摘

Fostriecin and related natural products present a significant challenge for synthetic chemists due to their structural complexity and chemical sensitivity. This review will chronicle the successful efforts of synthetic chemists in the construction of these biologically active molecules. Key carbon–carbon bond forming reactions will be highlighted, as well as the methods used to install the numerous stereocenters present in this class of compounds.