Amelioration of Experimental Autoimmune Encephalomyelitis by Isogarcinol Extracted from Garcinia mangostana L. Mangosteen

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• 作者：Mengqi Wang ; Yufei Xie ; Youxiu Zhong ; Juren Cen ; Lei Wang ; Yuanyuan Liu ; Ying Zhu ; Li Tong ; Qun Wei
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2016
• 出版时间：November 30, 2016
• 年：2016
• 卷：64
• 期：47
• 页码：9012-9021
• 全文大小：658K
• ISSN：1520-5118

文摘

Isogarcinol is a new natural immunosuppressant that was extracted from Garcinia mangostana L. in our laboratory. Knowledge of its effects on treatable diseases and its mechanism of action is still very limited. In this study, we explored the therapeutic effect of isogarcinol in experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS). Treatment with oral 100 mg/kg isogarcinol markedly ameliorated clinical scores, alleviated inflammation and demyelination of the spinal cord, and reduced intracranial lesions in EAE mice. The percentages of Th cells and macrophages were also strongly reduced. Isogarcinol appeared to act by inhibiting T helper (Th) 1 and Th17 cell differentiation via the janus kinase/signal transducers and activators of transcription pathway and by impairing macrophage function. Our data suggest that isogarcinol has the potential to be an effective therapeutic agent of low toxicity for treating MS and other autoimmune diseases.