Rh(III)-Catalyzed meta-C–H Olefination Directed by a Nitrile Template

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• 作者：Hua-Jin Xu ; Yi Lu ; Marcus E. Farmer ; Huai-Wei Wang ; Dan Zhao ; Yan-Shang Kang ; Wei-Yin SunJin-Quan Yu
• 刊名：Journal of the American Chemical Society
• 出版年：2017
• 出版时间：February 15, 2017
• 年：2017
• 卷：139
• 期：6
• 页码：2200-2203
• 全文大小：439K
• ISSN：1520-5126

文摘

A range of Rh(III)-catalyzed ortho-C–H functionalizations have been developed; however, extension of this reactivity to remote C–H functionalizations through large-ring rhodacyclic intermediates has yet to be demonstrated. Herein we report the first example of the use of a U-shaped nitrile template to direct Rh(III)-catalyzed remote meta-C–H activation via a postulated 12-membered macrocyclic intermediate. Because the ligands used for Rh(III) catalysts are significantly different from those of Pd(II) catalysts, this offers new opportunities for future development of ligand-promoted meta-C–H activation reactions.