Amide-Ligand-Controlled Highly para-Selective Arylation of Monosubstituted Simple Arenes with Arylboronic Acids

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• 作者：Yu-Xin Luan ; Tao Zhang ; Wei-Wei Yao ; Ke Lu ; Lu-Yao Kong ; Yu-Tong Lin ; Mengchun Ye
• 刊名：Journal of the American Chemical Society
• 出版年：2017
• 出版时间：February 8, 2017
• 年：2017
• 卷：139
• 期：5
• 页码：1786-1789
• 全文大小：439K
• ISSN：1520-5126

文摘

Pd-catalyzed highly para-selective arylations of monosubstituted simple arenes with arylboronic acids to widely existed biaryls have been developed. Inspired by requisite amide-directing groups in reported selective oxidative couplings, amide ligands, especially DMF, are designed and found to be critical for the selectivity control in current arylations.