Polymer-Stabilized Perfluorobutane Nanodroplets for Ultrasound Imaging Agents

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• 作者：Yuran Huang ; Alexander M. Vezeridis ; James Wang ; Zhao Wang ; Matthew Thompson ; Robert F. Mattrey ; Nathan C. Gianneschi
• 刊名：Journal of the American Chemical Society
• 出版年：2017
• 出版时间：January 11, 2017
• 年：2017
• 卷：139
• 期：1
• 页码：15-18
• 全文大小：408K
• ISSN：1520-5126

文摘

In this paper, we describe a method for the stabilization of low-boiling point (low-bp) perfluorocarbons (PFCs) at physiological temperatures by an amphiphilic triblock copolymer which can emulsify PFCs and be cross-linked. After UV-induced thiol–ene cross-linking, the core of the PFC emulsion remains in liquid form even at temperatures exceeding their boiling points. Critically, the formulation permits vaporization at rarefactional pressures relevant for clinical ultrasound.