Bifunctional Photocatalysts for Enantioselective Aerobic Oxidation of β-Ketoesters

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• 作者：Wei Ding ; Liang-Qiu Lu ; Quan-Quan Zhou ; Yi Wei ; Jia-Rong ChenWen-Jing Xiao
• 刊名：Journal of the American Chemical Society
• 出版年：2017
• 出版时间：January 11, 2017
• 年：2017
• 卷：139
• 期：1
• 页码：63-66
• 全文大小：418K
• ISSN：1520-5126

文摘

A novel visible-light-responsive chiral ligand has been developed by grafting a triplet state photosensitizer to chiral bisoxazoline ligands. Complexation of this ligand with Ni(acac)₂ results in a powerful catalyst for the asymmetric oxidation reaction of β-ketoesters, which uses oxygen or air as the green oxidant and visible light or sunlight as the ideal driving force. Using this protocol, products containing the α-hydroxy-β-dicarbonyl motif are produced in high yields and with excellent enantiopurities.