Measurement and Correlation of Solubility on Reactive Crystallization of Methyl D-(−)-4-Hydroxy-phenylglycinate

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• 作者：Weiwei Hu ; Shui Wang ; Aizhen Liang ; Jidong Wang
• 刊名：Journal of Chemical & Engineering Data
• 出版年：2017
• 出版时间：January 12, 2017
• 年：2017
• 卷：62
• 期：1
• 页码：69-79
• 全文大小：379K
• ISSN：1520-5134

文摘

In this paper, the solubility of methyl D-(−)-4-hydroxy-phenylglycinate was measured under the different pH levels, pure solvents, mixed solvents, ionic strength, and impurities in the temperature range from 283 to 323 about 5 K intervals by using laser method at atmospheric pressure. The results reveal that the solubility of methyl D-(−)-4-hydroxy-phenylglycinate increases with increasing temperature in all selected solvents, which decreases with increasing mole fraction composition of water in the mixed solvents. The solubility curve of methyl D-(−)-4-hydroxy-phenylglycinate in the aqueous solution at different pH is “U” shape and the solubility of methyl D-(−)-4-hydroxy-phenylglycinate increases with concentrations of ammonium chloride and has no obvious changes when its concentration increases up to 1.25 mol/kg. It is beneficial to maximize the reaction conversion rate of D-4-hydroxyphenylglycine methyl ester hydrochloride and reduce the residual D-4-hydroxyphenylglycine methyl ester hydrochloride on reactive crystallization of methyl D-(−)-4-hydroxy-phenylglycinate. Furthermore, the modified Apelblat equation and C_T = C₀(α_H⁺/k₁ + k₂/α_H⁺ + 1) type correlation regression model have made good correlation of the experimental solubility in pure solvents, mixed solvents, and the aqueous solution at different pH, respectively.