ent-Strobane and ent-Pimarane Diterpenoids from Siegesbeckia pubescens

详细信息    查看全文

• 作者：Jianbin WangHongquan Duan ; Yi Wang ; Bowen Pan ; Chun Gao ; Chunyan Gai ; Qiong Wu ; Hongzheng Fu
• 刊名：Journal of Natural Products
• 出版年：2017
• 出版时间：January 27, 2017
• 年：2017
• 卷：80
• 期：1
• 页码：19-29
• 全文大小：556K
• ISSN：1520-6025

文摘

Two strobane diterpenoids, strobols A (1) and B (2), 15 new pimarane diterpenoids (3–6 and 8–18), and the known compounds kirenol (19), darutigenol (20), and ent-2β,15,16,19-tetrahydroxypimar-8(14)-ene (7) were isolated from the aerial parts of Siegesbeckia pubescens Makino. The structures of the new compounds were established based on the interpretation of HRESIMS and NMR analysis. The configurations of 1, 6, and 17 were confirmed by X-ray crystallographic data. Compounds 3, 5, and 11 inhibited the migration of MB-MDA-231 breast cancer cells induced by the chemokine epithelial growth factor, with IC₅₀ values of 4.26, 3.45, and 9.70 μM, respectively.