Spiro Meroterpenoids from Ganoderma applanatum

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• 作者：Qi Luo ; Xiao-Yi Wei ; Jing Yang ; Jin-Feng Luo ; Rui Liang ; Zheng-Chao Tu ; Yong-Xian Cheng
• 刊名：Journal of Natural Products
• 出版年：2017
• 出版时间：January 27, 2017
• 年：2017
• 卷：80
• 期：1
• 页码：61-70
• 全文大小：640K
• ISSN：1520-6025

文摘

Spiroapplanatumines A–Q (1–12, 14–16, 18, and 20), new spiro meroterpenoids respectively bearing a 6/5/7 or 6/5/5 ring system, along with three known compounds, spirolingzhines A, B, and D, were isolated from the fruiting bodies of the fungus Ganoderma applanatum. Their structures including absolute configurations were assigned by using spectroscopic methods, ECD and ¹³C NMR calculations, and single-crystal X-ray diffraction analysis. Biological evaluation of all the compounds disclosed that compounds 7 and 8 inhibited JAK3 kinase with IC₅₀ values of 7.0 ± 3.2 and 34.8 ± 21.1 μM, respectively.