Penicisulfuranols A–F, Alkaloids from the Mangrove Endophytic Fungus Penicillium janthinellum HDN13-309

详细信息    查看全文

• 作者：Meilin Zhu ; Xiaomin Zhang ; Huimin Feng ; Jiajia Dai ; Jing Li ; Qian Che ; Qianqun Gu ; Tianjiao Zhu ; Dehai Li
• 刊名：Journal of Natural Products
• 出版年：2017
• 出版时间：January 27, 2017
• 年：2017
• 卷：80
• 期：1
• 页码：71-75
• 全文大小：281K
• ISSN：1520-6025

文摘

Six new epipolythiodioxopiperazine (ETP) alkaloids, penicisulfuranols A–F (1–6), were isolated from the mangrove endophytic fungus Penicillium janthinellum HDN13-309. All structures including absolute configurations were elucidated on the basis of comprehensive spectroscopic data and ECD calculations. They belong to the unusual family of ETPs containing sulfur atoms on both α- and β-positions of amino acid residues and a rare 1,2-oxazadecaline core moiety. In addition, compounds 1–6 also possess a rare spiro-furan ring and 1–3 showed cytotoxicity with IC₅₀ values ranging from 0.1 to 3.9 μM.