Monascustin, an Unusual γ-Lactam from Red Yeast Rice

详细信息    查看全文

• 作者：Wendi Wei ; Sheng Lin ; Minghua Chen ; Tianxi Liu ; Ali Wang ; Jinjie Li ; Qinglan Guo ; Xiaoya Shang
• 刊名：Journal of Natural Products
• 出版年：2017
• 出版时间：January 27, 2017
• 年：2017
• 卷：80
• 期：1
• 页码：201-204
• 全文大小：293K
• ISSN：1520-6025

文摘

Monascustin (1), an unusual γ-lactam, was isolated from an ethanol extract of the Monascus purpureus fermented rice. Its structure including the absolute configuration was determined by spectroscopic data analysis and confirmed by X-ray crystallography. A plausible biosynthetic pathway is discussed on the basis of amino acid derivatization. Compound 1 showed inhibitory activity against histone deacetylase 1.