Antimicrobial Oligophenalenone Dimers from the Soil Fungus Talaromyces stipitatus

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• 作者：Yi Zang ; Grégory Genta-Jouve ; Alexandre E. Escargueil ; Annette K. Larsen ; Laura Guedon ; Bastien Nay ; Soizic Prado
• 刊名：Journal of Natural Products
• 出版年：2016
• 出版时间：December 23, 2016
• 年：2016
• 卷：79
• 期：12
• 页码：2991-2996
• 全文大小：352K
• ISSN：1520-6025

文摘

New polyketide-derived oligophenalenone dimers, 9a-epi-bacillisporin E (1) and bacillisporins F–H (2–5), along with the known bacillisporin A (6), were isolated from the fungus Talaromyces stipitatus. Their structures and absolute configurations were determined on the basis of spectroscopic analyses, electronic circular dichroism, and GIAO NMR shift calculation followed by DP4 analysis. The antimicrobial activity of these compounds was evaluated against a panel of human pathogenic bacteria. Among them, bacillisporin H (5) exhibited antimicrobial activity together with modest cytotoxicity against HeLa cells.