Use of a Cyclometalated Iridium(III) Complex Containing a N∧C∧N-Coordinating Terdentate Ligand as a Catalyst for the α-Alkylation of Ketones and N-Alkylation of Amines with Alcohols

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• 作者：Pengcheng Liu ; Ran Liang ; Lei Lu ; Zhentao Yu ; Feng Li
• 刊名：Journal of Organic Chemistry
• 出版年：2017
• 出版时间：February 17, 2017
• 年：2017
• 卷：82
• 期：4
• 页码：1943-1950
• 全文大小：521K
• ISSN：1520-6904

文摘

A cyclometalated iridium(III) complex containing a N^∧C^∧N-coordinating terdentate ligand [Ir(dpyx-N,C,N)Cl(μ-Cl)]₂ was found to be a general and highly effective catalyst for the α-alkylation of ketones and N-alkylation of amines with alcohols. In the presence of catalyst (1 mol % Ir) and base (0.2–0.5 equiv), a variety of desirable products were obtained in good yields under an air atmosphere. Notably, this research exhibited the new potential of Ir(III) complexes bearing non-Cp* ligand and will facilitate the progress of the hydrogen autotransfer process.