Visible-Light-Induced C2 Alkylation of Pyridine N-Oxides

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• 作者：Wen-Man Zhang ; Jian-Jun Dai ; Jun Xu ; Hua-Jian Xu
• 刊名：Journal of Organic Chemistry
• 出版年：2017
• 出版时间：February 17, 2017
• 年：2017
• 卷：82
• 期：4
• 页码：2059-2066
• 全文大小：576K
• ISSN：1520-6904

文摘

A photoredox catalytic method has been developed for the direct C2 alkylation of pyridine N-oxides. This reaction is compatible with a range of synthetically relevant functional groups for providing efficient synthesis of a variety of C2-alkylated pyridine N-oxides under mild conditions. Mechanistic studies are consistent with the generation of a radical intermediate along the reaction pathway.