Synthesis of Isocoumarins from Cyclic 2-Diazo-1,3-diketones and Benzoic Acids via Rh(III)-Catalyzed C–H Activation and Esterification

详细信息    查看全文

• 作者：Cheng Yang ; Xinwei He ; Lanlan Zhang ; Guang Han ; Youpeng Zuo ; Yongjia Shang
• 刊名：Journal of Organic Chemistry
• 出版年：2017
• 出版时间：February 17, 2017
• 年：2017
• 卷：82
• 期：4
• 页码：2081-2088
• 全文大小：518K
• ISSN：1520-6904

文摘

A mild and efficient Rh(III)-catalyzed C–H activation/esterification reaction for the synthesis of isocoumarins has been developed. This procedure uses readily available benzoic acids and cyclic diazo-1,3-diketones as starting materials and involves domino intermolecular C–H activation in combination with intramolecular esterification to give the corresponding isocoumarins in moderate to excellent yields. This process provides a facile approach for the construction of isocoumarins containing various functional groups that does not require any additives.