Oxidative Recyclization of 1H-Indoles for Synthesis of 2-Indolylbenzoxazinones via Cleavage of the C2–C3 Bond with AIBN under Air

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• 作者：Xing-Xing Liu ; Xin-Liang Luo ; Zhao-Yang Wu ; Xin-Feng Cui ; Xiao-Qiang Zhou ; Yong-Qin He ; Guo-Sheng Huang
• 刊名：Journal of Organic Chemistry
• 出版年：2017
• 出版时间：February 17, 2017
• 年：2017
• 卷：82
• 期：4
• 页码：2107-2113
• 全文大小：462K
• ISSN：1520-6904

文摘

A novel and concise method for the oxidation of unprotected indole derivatives to synthesize 2-indolylbenzoxazinones in the presence of AIBN under open air has been successfully demonstrated. This metal-free reaction is both atom- and step-efficient and is applicable to a broad scope of substrates. This new methodology provides a facile pathway for oxidative C2–C3 bond cleavage and recyclization of 1H-indoles.