Cobalt-Catalyzed Biaryl Couplings via C–F Bond Activation in the Absence of Phosphine or NHC Ligands

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• 作者：Juan Wei ; Kun-Ming Liu ; Xin-Fang Duan
• 刊名：Journal of Organic Chemistry
• 出版年：2017
• 出版时间：February 3, 2017
• 年：2017
• 卷：82
• 期：3
• 页码：1291-1300
• 全文大小：562K
• ISSN：1520-6904

文摘

A highly general and selective Co-catalyzed biaryl coupling through C–F cleavage under phosphine or NHC-free conditions was described. A broad range of aryl fluorides including unactivated fluorides as well as those with sensitive functionalities could couple with various Ti(OEt)₄-mediated aryl Grignard reagents with high selectivity under the catalysis of CoCl₂/DMPU. Importantly, selective C–F bond activation couplings between two types of fluorines (difluorinated aromatics and on two different coupling partners) and in the presence of C–Cl or C–Br bonds could also be achieved.