Palladium-Catalyzed Ortho-Alkoxylation of N-Benzoyl α-Amino Acid Derivatives at Room Temperature

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• 作者：Shuangjie Li ; Wei Zhu ; Feng Gao ; Chunpu Li ; Jiang Wang ; Hong Liu
• 刊名：Journal of Organic Chemistry
• 出版年：2017
• 出版时间：January 6, 2017
• 年：2017
• 卷：82
• 期：1
• 页码：126-134
• 全文大小：511K
• ISSN：1520-6904

文摘

An efficient palladium-catalyzed ortho-alkoxylation of N-benzoyl α-amino acid derivatives at room temperature has been explored. This novel transformation, using amino acids as directing groups, Pd(OAc)₂ as catalyst, alcohols as the alkoxylation reagents, and PhI(OAc)₂ as the oxidant, showed wide generality, good functional tolerance, and high monoselectivity and regioselectivity.