P(NMe2)3-Mediated Aziridination of Imines with α-Ketoesters for Synthesis of Aziridine-2-carboxylates

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• 作者：Jin Jiang ; Hui Liu ; Chong-Dao LuYan-Jun Xu
• 刊名：Journal of Organic Chemistry
• 出版年：2017
• 出版时间：January 6, 2017
• 年：2017
• 卷：82
• 期：1
• 页码：811-818
• 全文大小：410K
• ISSN：1520-6904

文摘

Aziridination of N-sulfonyl imines with α-ketoesters in the presence of P(NMe₂)₃ is reported. Adducts derived from trivalent phosphorus reagents and α-ketoesters are effectively intercepted by imines, affording a range of aziridine-2-carboxylates. The diastereoselectivity of the reaction depends on steric hindrance from substituents on the substrates.