Assembly of Polysubstituted Maleimides via Palladium-Catalyzed Cyclization Reaction of Alkynes with Isocyanides

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• 作者：Weigao Hu ; Jia Zheng ; Jianxiao Li ; Bifu Liu ; Wanqing Wu ; Haiyang Liu ; Huanfeng Jiang
• 刊名：Journal of Organic Chemistry
• 出版年：2016
• 出版时间：December 16, 2016
• 年：2016
• 卷：81
• 期：24
• 页码：12451-12458
• 全文大小：496K
• ISSN：1520-6904

文摘

An efficient and convenient palladium-catalyzed cyclization reaction of alkynes with isocyanides is described herein. This protocol allows the practical synthesis of many valuable polysubstituted maleimide derivatives after hydrolysis with a broad scope of substrates and mild reaction conditions. C–C, C═O, and C–N bonds were constructed in this transformation with isocyanide serving as both C and N sources.