Salecan-Based pH-Sensitive Hydrogels for Insulin Delivery

详细信息    查看全文

• 作者：Xiaoliang Qi ; Wei Wei ; Junjian Li ; Gancheng Zuo ; Xihao Pan ; Ting Su ; Jianfa Zhang ; Wei Dong
• 刊名：Molecular Pharmaceutics
• 出版年：2017
• 出版时间：February 6, 2017
• 年：2017
• 卷：14
• 期：2
• 页码：431-440
• 全文大小：651K
• ISSN：1543-8392

文摘

Stimuli-responsive polymeric hydrogels are promising and appealing delivery vehicles for protein/peptide drugs and have made protein/peptide delivery with both dosage- and spatiotemporal-controlled manners possible. Here a series of new Salecan-based pH-sensitive hydrogels were fabricated for controlled insulin delivery via the graft copolymerization reaction between Salecan and 2-acrylamido-2-methyl-1-propanesulfonic acid. In this study, on one hand, Salecan played a key role in modifying the structure and the pore size of the developing hydrogel. On the other hand, Salecan tuned the water content and the water release rate of the obtained hydrogel, leading to a controllable release rate of the insulin. More importantly, in vitro release experiments validated that the release of insulin from this intelligent system could be also tailored by the environmental pH of the release medium. For SGA2, the amount of encapsulated insulin released at gastric conditions (pH 1.2) was relatively low (about 26.1 wt % in 24 h), while that released at intestinal conditions (pH 7.4) increased significantly (over 50 wt % in 6 h). Furthermore, toxicity assays demonstrated that the designed hydrogel carriers were biocompatible. These characteristics make the Salecan-based hydrogel a promising candidate for protein/peptide drug delivery device.