Self-Targeted Polysaccharide Prodrug Suppresses Orthotopic Hepatoma

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• 作者：Di Li ; Weiguo Xu ; Pengqiang Li ; Jianxun Ding ; Zhiliang Cheng ; Li Chen ; Lesan Yan ; Xuesi Chen
• 刊名：Molecular Pharmaceutics
• 出版年：2016
• 出版时间：December 5, 2016
• 年：2016
• 卷：13
• 期：12
• 页码：4231-4235
• 全文大小：315K
• ISSN：1543-8392

文摘

Self-targetability is an emerging targeting strategy for polymer nanocarriers with facile preparation and high targeting efficiency. An acid-sensitive dextran–doxorubicin prodrug (Dex-g-DOX) has been synthesized and used as a self-targeted drug delivery system for the treatment of orthotopic hepatoma. The polysaccharide prodrug exhibits ultraselective accumulation in cancerous liver tissue, acid-sensitive DOX release within cells, and high antitumor efficacy in vitro and in vivo. Therefore, Dex-g-DOX demonstrates great potential for chemotherapy of orthotopic hepatoma.